Ye Zhi

1.Personal Profile

Name：Ye Zhi

Degree：Ph.D.

Title：Associate Professor

Email：yezhi@ouc.edu.cn

2.Teaching course

Biotechnology

3.Experiment skill training

My research interest focuses on the molecular genetics and developmental biology of marine animals with economic potential (eg. fish and shrimp). Taking advantages of the state-of-the-art biotechnologies and methodologies such as high-throughput DNA sequencing, transgenic and gene editing (CRISPR/Cas9) systems, genome-wide associated study (GWAS) et. al., we aim to unveil the molecular mechanisms that regulate the biological process of economic traits such as coloration, growth and disease resistance, as well as the genetic basis that leads to the variation of these traits in different individuals/families. Our ultimate goal is to use these knowledges to produce/breed superior aquaculture animals with high quality and low producing cost.

4.Research results

Representative papers:

Ye, Z., Braden, C., Wills, A., and Kimelman, D. (2021). Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression. Development 148: dev199408. doi:10.1242/dev.199408. (Interviewed by Science in Seattle)

Ye, Z. and Kimelman, D. (2020). Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development 147. (Highlighted and interviewed by Development)

Elaswad, A., Khalil, K., Ye, Z.†, Liu, Z., Liu, S., Peatman, E., Odin, R., Vo, K., Drescher, D., Gosh, K., et al. (2018). Effects of CRISPR/Cas9 dosage on TICAM1 and RBL gene mutation rate, embryonic development, hatchability and fry survival in channel catfish. Sci Rep 8, 16499. (†：Corresponding author)

Hou, Z.*, Ye, Z.*, Zhang, D., Gao, C., Su, B., Song, L., Tan, F., Song, H., Wang, Y. and Li, C. (2017). Characterization and expression profiling of NOD-like receptor C3 (NLRC3) in mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge. Fish & Shellfish Immunology 66, 231–239. (*: Co-first author)

Dong, X.*, Ye, Z.*, Song, L., Su, B., Zhao, H., Peatman, E. and Li, C. (2016). Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge. Fish Shellfish Immunol. 48, 112–118. (*: Co-first author)