高珊

一、个人简介

姓名：高珊

学历：博士研究生

职称：教授

办公电话：0532-82031935

邮箱：shangao@ouc.edu.cn

二、在海德教授课程名称

分子生物学

三、研究方向

以单细胞真核生物四膜虫为主要模式材料，研究DNA N6-腺嘌呤甲基化的调控酶体系和遗传机理，以及复制转录冲突的协同调控机制。

四、研究成果

国家自然科学基金杰出青年基金

国家自然科学基金优秀青年基金

国家万人计划青年拔尖人才计划

1.Yuanyuan Wang, Yalan Sheng, Yongqiang Liu, Wenxin Zhang, Ting Cheng, Lili Duan, Bo Pan, Yu Qiao, Yifan Liu, Shan Gao* (2019). A distinct class of eukaryotic MT-A70 methyltransferases maintain symmetric DNA N⁶-adenine methylation at the ApT dinucleotides as an epigenetic mark associated with transcription. Nucleic Acids Research, 47, 11771-11789.

2.Jing Xu, Xiaolu Zhao, Fengbiao Mao, Venkatesha Basrur, Beatrix Ueberheide, Brian T. Chait, C. David Allis, Sean D. Taverna, Shan Gao*, Wei Wang*, Yifan Liu* (2021). A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies. Nucleic Acids Research, 2021, 49, 5407-5425. 2021 NAR breakthrough article

3.Xiaolu Zhao, Jie Xiong, Fengbiao Mao, Yalan Sheng, Xiao Chen, Lifang Feng, Wen Dui, Wentao Yang, Aurelie Kapusta, Cedric Feschotte, Rebert s. Coyne, Wei Miao, Shan Gao*, Yifan Liu* (2019). RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena. Genes & Development, 33, 348-364